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edition: 1 Authors: Patrick Forterre (auth.), Yves Pommier (eds.) serie: Cancer Drug Discovery and Development ISBN : 1461403227, 9781461403227 publisher: Springer-Verlag New York publish year: 2012 pages: 444 language: English ebook format : PDF (It will be converted to PDF, EPUB OR AZW3 if requested by the user) file size: 5 MB
Front Matter....Pages i-xi
Introduction and Historical Perspective....Pages 1-52
Human DNA Topoisomerase I: Structure, Enzymology and Biology....Pages 53-69
Mitochondrial Topoisomerases....Pages 71-85
Structure and Mechanism of Eukaryotic Type IIA Topoisomerases....Pages 87-101
Essential Functions of Topoisomerase IIIα in the Nucleus and Mitochondria....Pages 103-117
DNA Topoisomerase I and Illegitimate Recombination....Pages 119-143
Topoisomerase-Induced DNA Damage....Pages 145-154
Topoisomerases and Carcinogenesis: Topoisomerase IIIα and BLM....Pages 155-173
Topoisomerases Inhibitors: A Paradigm for Interfacial Inhibition....Pages 175-184
Topoisomerase I Inhibitors: Chemical Biology....Pages 185-210
Topoisomerase II Inhibitors: Chemical Biology....Pages 211-243
Topoisomerase I Inhibitors: Current Use and Prospects....Pages 245-277
Topoisomerase II Inhibitors: Current Use and Prospects....Pages 279-307
Transcriptional Stress by Camptothecin: Mechanisms and Implications for the Drug Antitumor Activity....Pages 309-324
Mechanisms Regulating Cellular Responses to DNA Topoisomerase I-Targeted Agents....Pages 325-334
Tyrosyl-DNA-Phosphodiesterase....Pages 335-354
Ubiquitin and Ubiquitin-Like Proteins in Repair of Topoisomerase-Mediated DNA Damage....Pages 355-379
Repair of Topoisomerase II-Mediated DNA Damage: Fixing DNA Damage Arising from a Protein Covalently Trapped on DNA....Pages 381-407
Topoisomerases and Apoptosis....Pages 409-435
Back Matter....Pages 437-443
